![]() The researchers plan to confirm the results by analysing blood samples from lung cancer patients. Other tests identified which RNAs are packaged into extracellular vesicles and preferentially secreted from cancerous cells affected by mutant KRAS. Computer simulations identified prevalent RNA compared to control cells.Īdditional epigenomic profiling looked at how genes are turned on or off without changes to the DNA sequence itself. They performed RNA sequencing using several different methods. In Petri dishes the researchers introduced mutant KRAS into healthy lung cells, pushing them into a cancerous state. ![]() ![]() Some tumours shed DNA into the blood a long time before a person would start experiencing symptoms.Īround 360,000 people are diagnosed with cancer in the UK every year – equivalent to nearly 1,000 cases a day. This could be done through a minimally invasive technique called ‘liquid biopsy’ rather than traditional tumour tissue surgery. Lab experiments found cancer triggering variants wrongly activate others – that can be detected in the blood through sequencing, or mapping.ĭr Kim believes it is a very promising tool for for diagnosing cancer in its earliest stages. It works by looking for chemical changes in fragments of genetic code that leak from tumours into the bloodstream.
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